Publications

2025

Rapid restoration of cell phenotype and matrix forming capacity following transient nuclear softening
Locke RC, Miller LM, Lemmon EA, Assi SS, Jones DL, Bonnevie ED, Burdick JA, Heo SJ, Mauck RL.
Acta Biomaterialia. 2025. PMID - 41072595

YAP regulates transcriptional programs for layer-specific periosteal expansion during fracture repair
Nijsure MP, Tobin B, Jones DL, Lang A, Hallstrom G, Baitner M, Tanner GI, Kotsaris G, Maharrer Y, Panebianco CJ, Seidl EG, Dyment NA, Szeto GL, Wood L, Boerckel JD.
Science Advances. 2025. PMID - 40768586

2024

An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung
Jones DL, Morley MP, Li X, Ying Y, Zhao G, Schaefer SE, Rodriguez LR, Cardenas-Diaz FL, Li S, Zhou S, Chembazhi UV, Kim M, Shen C, Nottingham A, Lin S, Cantu E, Diamond JM, Basil MC, Vaughan AE, Morrisey EE.
Science. 2024. PMID - 39666855

Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease
Shiraishi K, Morley MP, Jones DL, Zhao G, Weiner AI, Basil MC, Cantu E, Ferguson LT, Oyster M, Babu A, Ying Y, Zhou S, Li S, Vaughan AE, Morrisey EE.
NPJ Regenerative Medicine. 2024. PMID - 38182591

2023

Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
Shiraishi K, Shah PP, Morley MP, Loebel C, Santini GT, Katzen J, Basil MC, Lin SM, Planer JD, Cantu E, Jones DL, Nottingham A, Li S, Cardenas-Diaz FL, Zhou S, Burdick JA, Jain R, Morrisey EE.
Cell. 2023. PMID - 36870331

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz
Jones DL, Hallstrom GF, Jiang X, Evans MK, Bonnevie ED, Srikumar A, Nijsure MP, Boerckel JD, Mauck RL, Dyment NA.
Proceedings of the National Academy of Sciences. 2023. PMID - 37216538

Microenvironmental mechanoactivation through Yap/Taz suppresses chondrogenic gene expression
Hallstrom GF, Jones DL, Locke RC, Bonnevie ED, Kim S-Y, Laforest L, Garcia DC, Mauck RL.
Molecular Biology of the Cell. 2023. PMID - 37043309

DRD1 is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts
Gao AY, Diaz Espinosa AM, Nguyen BBN, Jones DL, Gibbard DF, Tschumperlin DJ, Haak AJ.
The Journal of Pharmacology and Experimental Therapeutics. 2023. PMID - 37024146

2022

Dysregulation of the transcription factor ERG in aging lung impairs lung vascular repair and promotes persistent fibrosis
Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G.
Nature Communications. 2022. PMID - 35879310

Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis
Pham TX, Lee J, Guan J, Caporarello N, Meridew JA, Jones DL, Tan Q, Huang SK, Tschumperlin DJ, Ligresti G.
JCI Insight. 2022. PMID - 35167499

Combined control of the fibroblast contractile program by YAP and TAZ
Link PA, Choi KM, Diaz Espinosa AM, Jones DL, Haak AJ, Tschumperlin DJ.
AJP Lung Cellular and Molecular Physiology. 2022. PMID - 34755530

2021

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation
Jones DL, Meridew JA, Link PA, Ducharmme MT, Lydon KT, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ.
Journal of Cell Biology. 2021. PMID - 33625469

2020

Vascular dysfunction in aged mice contributes to persistent lung fibrosis
Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti G.
Aging Cell. 2020. PMID - 32691484

TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation
Aravamudhan A, Haak AJ, Choi KM, Meridew JA, Caporarello N, Jones DL, Tan Q, Ligresti G, Tschumperlin DJ.
AJP Lung Cellular and Molecular Physiology. 2020. PMID - 32159970

2019

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt R, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ.
Science Translational Medicine. 2019. PMID - 31666402

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression
Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ.
Journal of Cell Science. 2019. PMID - 31527052

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory, and fibrogenic state
Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G.
Thorax. 2019. PMID - 31182654

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis
Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.
JCI Insight. 2019. PMID - 31095524

Nascent lung organoids reveal epithelium- and BMP-mediated suppression of fibroblast activation
Tan Q, Ma XY, Liu W, Meridew JA, Jones DL, Haak AJ, Sicard D, Ligresti G, Tschumperlin DJ.
American Journal of Respiratory Cell and Molecular Biology. 2019. PMID - 31050552